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Latest "Past Grant Recipients" Posts

The Myocarditis Foundation Welcomes Previous Fellowship Grant Recipient to the Medical Advisory Board!

Dr. Bettina Heidecker, the 2007 Myocarditis Foundation Fellowship Grant recipient, has just been appointed to the Myocarditis Foundation Medical Advisory Board. Dr. Heidecker’s title of her research at that time was: “Gene Expression Profiling for Detection of Myocarditis.”

Since that time, Dr. Heidecker, has worked with Dr. Joshua Hare at the University of Miami Interdisciplinary Stem Cell Institute as a Post-Doctoral Fellow and Co-Principal Investigator, (2007-2009) studying transcriptomic biomarkers for new onset heart failure and to further develop the diagnostic biomarker for myocarditis.

Dr. Heidecker also completed her residency training at the University of Miami in Internal Medicine (2009-2012) as well as a Cardiology fellowship at the University of California, San Francisco (2012-2015) while continuing her research in myocarditis.

Posted by Myocarditis Foundation in Past Grant Recipients, Press Releases.

The Myocarditis Foundation Announces its 2015 Grant Recipient for the 2016/2017 Grant Cycle

The Myocarditis Foundation is pleased to announce that it will be funding a research fellowship grant for the 2016/2017 grant cycle. The Myocarditis Foundation will be awarding the research grant to Dr. Jon Sin of Cedars-Sinai Medical Center in the amount of $40,000. Dr. Sin is under the mentorship of Dr. Ralph Feuer of Cedars-Sinai Medical Center.

Jon Sin

The Myocarditis Foundation, an international non-profit organization founded in 2005, is dedicated to increasing awareness and hastening progress in understanding this rare disease. Myocarditis is a disease that is marked by inflammation and scarring of the heart muscle, which can progress rapidly to heart failure and death or heart transplantation.

Posted by Myocarditis Foundation in Awareness & Fundraising, Myocarditis News, Past Grant Recipients, Press Releases, Research News.

Success in Mentoring MF Grant Recipient

The Myocarditis Foundation awards grants for one year research fellowships to study myocarditis with the aim of encouraging young PhD and MD scientists to pursue a career involving myocarditis. As well as financial support the Foundation also provides mentoring support with career advice and assistance with networking. Recently one of our grant recipients, Dr. Bettina Heidecker MD, was highlighted in an article in a prestigious scientific journal the European Heart Journal (reference Eur Heart J (2015) 36:398-403). In this article Bettina states that “Myocarditis is a disease affecting many young individuals. Currently we lack sufficient understanding of its pathophysiology to improve specific treatment.

Posted by Myocarditis Foundation in Past Grant Recipients.

The Myocarditis Foundation Announces its 2014 Grant Recipient for the 2015/16 Grant Cycle

The Myocarditis Foundation is pleased to announce that it will be funding a research fellowship grant for the 2015/16 grant cycle.  The Myocarditis Foundation will be funding a research grant awarded to Dr. Michael Bode of the University of North Carolina in the amount of $35,000.  Dr. Bode is under the mentorship of Dr. Nigel Mackman of the University of North Carolina.

Michael Bod

The Myocarditis Foundation, an international non-profit organization founded in 2005, is dedicated to increasing awareness and hastening progress in understanding this rare disease.  Myocarditis is a disease that is marked by inflammation and scarring of the heart muscle, which can progress rapidly to heart failure and death or heart transplantation.

Posted by Myocarditis Foundation in Myocarditis News, Past Grant Recipients, Press Releases, Research News.

The Myocarditis Foundation Announces its 2013 Grant Recipient for the 2014/15 Grant Cycle

 The Myocarditis Foundation is pleased to announce that it will be funding a research fellowship grant for the 2014/15 grant cycle.  The Myocarditis Foundation will be funding a research grant awarded to Dr. Yuji Nagatomo of the Cleveland Clinic in the amount of $35,000.  Dr. Nagatomo is under the mentorship of Dr. Wilson Tang of the Cleveland Clinic.

 The Myocarditis Foundation, an international non-profit organization founded in 2005, is dedicated to increasing awareness and hastening progress in understanding this rare disease.  Myocarditis is a disease that is marked by inflammation and scarring of the heart muscle, which can progress rapidly to heart failure and death or heart transplantation.

Posted by Myocarditis Foundation in Myocarditis News, Past Grant Recipients, Press Releases, Research News.

The Myocarditis Foundation Awards Two Research Grants in 2012

The Myocarditis Foundation is pleased to announce that it will be funding two research fellowship grants for the 2013/14 grant cycle.  The Myocarditis Foundation will be funding a research grant awarded to Dr. Chandirasegaran Massilamany of the University of Lincoln in the amount of $35,000 and have co-sponsored a grant with the American Heart Association awarded to Brian Avanzino of the University of California Davis in the amount of $50,000, half of which will be funded by the Myocarditis Foundation.

Posted by Myocarditis Foundation in Myocarditis News, Past Grant Recipients, Press Releases.

Dr. Kevin Quinn of the University of California in Los Angeles

Awarded grant in 2012

Identifying Antiviral Agents to Treat Coxsackievirus Myocarditis

Dr. Kevin Quinn of the University of California in Los Angeles

“In support of a long-term goal of identifying potent and tolerable antiviral drugs to prevent enteroviral myocarditis, our project has the following 3 goals:

  1. To identify the compounds which most actively inhibit coxsackievirus replication in tissue culture cells
  2. To identify the mechanism of action that allows these viral inhibitors to prevent coxsackievirus from completing its lytic cycle
  3. To test the most active inhibitors in a mouse model of coxsackievirus myocarditis. Those effective in inhibiting coxsackievirus infection in animal models could in turn be evaluated towards application in human patients.”

Posted by Myocarditis Foundation in Past Grant Recipients, Press Releases.

Dr. Laure Case of the University of Vermont

Awarded grant in 2012

Chromosome Y Regulates usceptibility to Coxsackievirus
B3-induced Myocardtis

Dr. Laure Case of the University of Vermont

“The experiments proposed in this fellowship will identify the critical cell types, for example cardiomyocytes and/or immune cells, which influence myocarditis susceptibility in the consomic mice. Thisdata will provide the necessary cellular link for future work that tests the hypothesis that ChrY dependent regulation of genes on other chromosomes is evolutionarily conserved, and that this mechanism influences myocarditis susceptibility among male mice. This is a very novel and exciting area of genetic research that will reveal ChrY’s contribution to phenotypic differences that directly impact susceptibility to myocarditis and allow for the identification of genes and pathways that can be targeted for mechanistic studies and therapeutic intervention.”

Posted by Myocarditis Foundation in Past Grant Recipients, Press Releases.

Dr. Alan Valaperti of the University of Health Network at the University of Toronto in Canada

Awarded grant in 2011

IL-1 Receptor-associated Kinase 4 (IRAK4) Epigentically Modulates Nod2- and MDA5- dependent Protection in Viral Myocarditis

Dr. Alan Valaperti of the University of Health Network at the University of Toronto in Canada

“First we observed that the major cell population infiltrating into the inflamed heart of Coxsackie virus B3 (CVB3)-inoculated IRAK4 deficient mice were macrophages. We were able to show that upon in vitro infection with Coxackievirus B3 (CVB3), IRAK4 down-regulated IFN-α and IFN-γ, but not IFN-β, exclusively in macrophages, but not in myeloid dendritic cells or plasmacytoid dendritic cells. Simultaneous down-regulation of IFN-α and IFN-γ, which means up-regulation of IFN-α and IFN-γ in IRAK4 deficient cells, was enough to dramatically reduce viral replication in infected macrophages.”

“In addition, IRAK4 showed unique functions that were only partially shared with its upstream molecule MyD88.

Posted by Myocarditis Foundation in Past Grant Recipients, Press Releases.

Dr. Kathleen Simpson of Washington University in St. Louis, MO

Awarded grant in 2010

Autoimmunity in Pediatric Myocarditis: A Pilot Study

Dr. Kathleen Simpson of Washington University in St. Louis, MO

“The relationship of autoimmunity in the pathophysiology and outcomes of pediatric myocarditis is unknown. Through the collaboration of regional pediatric hospitals encompassing the states of Missouri, Oklahoma, and Nebraska, we plan to determine the relationship of autoimmunity to outcomes in previously and newly diagnosed pediatric myocarditis. In addition, we will use MRI of the heart to determine specific findings in children and the role of MRI in disease progression and prognosis for children with myocarditis. Improving the understanding of patient immune reaction in myocarditis may lead to improvement in prognosis and treatment in children.”

Posted by Myocarditis Foundation in Past Grant Recipients, Press Releases.