Impact of CardiolRx on Myocardial Recovery in Acute Myocarditis

Impact of CardiolRx on Myocardial Recovery in Acute Myocarditis

Status: Recruiting

Conditions: Myocarditis


Massachusetts General Hospital
McGill University Health Care
MedStar Heart and Vascular Institute
Minneapolis Heart Institute Foundation
Palm Springs Community Health Centre
University of Alberta Hospital
University of Pennsylvania
University of Pittsburgh Medical Center
Virginia Commonwealth University


Washington, DC

Miami Lakes, Florida

Boston, Massachusetts

Minneapolis, Minnesota

Cleveland, Ohio

Malvern, Pennsylvania

Pittsburgh, Pennsylvania

Richmond, Virginia

Edmonton, Alberta, Canada

Montreal, Quebec, Canada

Contact Information:

Dr. Mark Hofmeyer [email protected]

Dr. Yanely Pineiro

Dr. Daniel Zlotoff [email protected]

Dr. David Lin [email protected]

Dr. Pavan Bhat [email protected]

Dr. Victor Ferrari [email protected]

Dr. Jessica Huston [email protected]

Dr. Roshanak Markley [email protected]

Dr. Justin Ezekowitz [email protected]

Dr. Matthias Friedrich [email protected]

“Multi-center, double-blind, placebo-controlled, parallel group design. Patients with myocarditis within 90 days of onset of symptoms will be screened and, if eligible, randomized to CardiolRx or placebo.
CardiolRx is pharmaceutically produced Cannabidiol and is free of tetrahydrocannabinol (THC<5 ppm). The treatment period is 12 weeks; a last follow-up visit is scheduled one week after the last treatment, 13 weeks after randomization. Study assessments include Cardiac Magnetic Resonance imaging (CMR), ECG monitoring, 24-hour Holter assessments, the Kansas City Cardiomyopathy Questionnaire (KCCQ), the Columbia-Suicide Severity Rating Scale (C-SSRS) as well as physical exams and laboratory tests. The primary outcome parameters are measured by CMR. Secondary outcomes include clinical endpoints and changes in inflammatory and biomarkers."

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