Dr. Kevin Quinn of the University of California in Los Angeles

Awarded grant in 2012

Identifying Antiviral Agents to Treat Coxsackievirus Myocarditis

“In support of a long-term goal of identifying potent and tolerable antiviral drugs to prevent enteroviral myocarditis, our project has the following 3 goals:

1. To identify the compounds which most actively inhibit coxsackievirus replication in tissue culture cells
2. To identify the mechanism of action that allows these viral inhibitors to prevent coxsackievirus from completing its lytic cycle
3. To test the most active inhibitors in a mouse model of coxsackievirus myocarditis. Those effective in inhibiting coxsackievirus infection in animal models could in turn be evaluated towards application in human patients.”