Clinical Trials

Are you or a loved one living with the challenges of myocarditis, pericarditis, or sarcoidosis? The Myocarditis Foundation is dedicated to improving the lives of those affected by these heart conditions, and you can play a vital role in advancing the cure. Participating in a clinical trial is not only an opportunity to receive cutting-edge medical care but also a chance to contribute to groundbreaking research that can transform the future of cardiac health. By joining a clinical trial, you become a beacon of hope for countless individuals around the world who yearn for better treatments and ultimately, a cure. Your participation can be the difference-maker in our journey towards a world without the burden of myocarditis, pericarditis, and sarcoidosis.

Clinical trials offer numerous benefits to participants beyond the potential for life-changing breakthroughs. When you participate, you receive close monitoring from leading healthcare experts who specialize in myocarditis, pericarditis, and sarcoidosis. You gain access to cutting-edge therapies, often before they become widely available, which can significantly improve your quality of life. Additionally, your involvement helps researchers gather critical data, paving the way for more targeted and effective treatments. Every trial participant is a hero in our quest to conquer these conditions, and your contribution is invaluable.

At the Myocarditis Foundation, we firmly believe that together, we can make a difference. We urge you to consider participating in a clinical trial as a powerful way to advocate for yourself and others affected by myocarditis, pericarditis, and sarcoidosis. However, it’s important to note that the Myocarditis Foundation is not affiliated with these research studies, and we are not accountable for the results or outcomes of specific clinical trials.

Join us in the fight against these heart conditions, and together, we can build a healthier and happier future for all.

Clinical Trials, What They Are and Why They Are So Important

Multimodal and Multidisciplinary Approach to optimize Diagnostic, Prognostic, and Therapeutic management of Patients with Nonischemic Cardiomyopathies and Arrhyhmogenic-Inflammatory phenotypes

Status: Recruiting

Brief Summary: nonischemic cardiomyopathies (NICM) constitute a heterogeneous group of diseases characterized by distinct structural and functional myocardial abnormalities in the absence of obstructive epicardial coronary artery disease. To date, there is a huge lack of knowledge related to two mai…

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Role of Endomyocardial Biopsy and Etiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management

Status: Recruiting

Brief Summary: this multicenter registry, both retrospective and prospective, aims at answering multiple questions about myocarditis, with special attention to arrhythmic manifestations. Patients with myocarditis proven at least by endomyocardial biopsy and/or cardiac magnetic resonance will be enro…

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Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

Status: Recruiting

Brief Summary: This study sets out to register imaging of small biopsy specimens obtained during bronchoscopy using full-field optical coherence tomography against standard histologic evaluation. Detailed Description: Small biopsy specimens obtained through bronchoscopy are commonly employed for the…

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Role of Novel ILR in the Management of PVCs

Status: Recruiting

Brief Summary: This prospective, observational study is a single center clinical registry of patients referred for management of symptomatic or asymptomatic Premature Ventricular Contractions (PVCs). Subjects will be followed through 12 months. The study will enroll approximately 50 patients. Detail…

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Pulmonary Care and Research Collaborative Patient Registry

Status: Recruiting

Brief Summary: The purpose of this research study is to build and maintain a registry of people with interstitial lung disease (ILD). Medical information collected for this registry may be used to advance ILD and pulmonary research and improve patient care. This is an observational registry. Partici…

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Rheumatology Patient Registry and Biorepository

Status: Recruiting

Brief Summary: To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases. Detailed Description: A rheumatology biorepository will be created to permit comparative analyses between the rheumatic diseases in order to increase the understanding…

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A Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis

Status: Not yet recruiting

Brief Summary: The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis.

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Mayo AVC Registry and Biobank

Status: Recruiting

Brief Summary: Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as…

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Interstitial Lung Disease Research Unit Biobank

Status: Recruiting

Brief Summary: Establish a interstitial lung disease (ILD) registry and biorepository to lead towards a further understanding of the disease. Detailed Description: The University of Kansas ILD and Rare Lung Disease clinic sees hundreds of new patients per year. The investigators would like to levera…

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A Study of the Natural Progression of Interstitial Lung Disease

Status: Recruiting

Brief Summary: We propose to acquire data and blood samples on all patients being cared for by the Interstitial Lung Disease (ILD) program. Additionally, we will collect data and blood samples from a control group for comparator purposes. In doing so, we will be able to describe the “phenotypic” exp…

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Role of Genetic Factors in the Development of Lung Disease

Status: Recruiting

Brief Summary: This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes…

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Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension

Status: Recruiting

Brief Summary: This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension. Detailed Description: Pulmonary sarcoidosis-associated pulmonary hypertension is classified as WHO Group 5 pulmonar…

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Diagnostic Yield of Intranodal Forceps Biopsies in Mediastinal Adenopathy

Status: Recruiting

Brief Summary: The investigators will compare endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) with intranodal forceps biopsy (EBUS-IFB) as it relates to the rate of diagnosis of suspected sarcoidosis. Detailed Description: This is prospective, single center randomized comparati…

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Cell Free DNA in Cardiac Sarcoidosis

Status: Recruiting

Brief Summary: Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing significant morbidity and mortality. Immunosuppressive ther…

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Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

Status: Recruiting

Brief Summary: This study sets out to register imaging of small biopsy specimens obtained during bronchoscopy using full-field optical coherence tomography against standard histologic evaluation. Detailed Description: Small biopsy specimens obtained through bronchoscopy are commonly employed for the…

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Medication Adherence in Patients With Sarcoidosis

Status: Recruiting

Brief Summary: The goal of the study is to look at the relationship between how individuals with Sarcoidosis take the sarcoidosis medicines and how it affects the disease, to evaluate any factors that may make individuals not want to take the medicines, and to develop and refine ways to help support…

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Evaluation of PET Probe [64]Cu-Macrin in Cardiovascular Disease, Cancer and Sarcoidosis.

Status: Recruiting

Brief Summary: To evaluate the safety of [64Cu] Macrin and its whole-body distribution, metabolism, pharmacokinetics, and radiation burden in healthy volunteers. To detect [64Cu]-Macrin accumulation in sites of disease in subjects with cancer, sarcoidosis or myocardial infarct. Detailed Description:…

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A Study to Assess the Efficacy and Safety of Namilumab in Participants With Chronic Pulmonary Sarcoidosis

Status: Recruiting

Brief Summary: This is a randomized, double-blind, placebo-controlled study with an open-label extension (OLE). Detailed Description: This is a randomized, double-blind, placebo-controlled study with an OLE. Participants will be randomized to receive namilumab or placebo in the 26-week Double-blind…

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Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis

Status: Recruiting

Brief Summary: Sarcoidosis is a heterogeneous disorder of unknown etiology whose signature lesions are granulomatous inflammatory infiltrates in involved tissues. Tissue commonly affected are lungs, skin, eyes, lymph nodes and the heart. In this latter case, cardiac sarcoidosis (CS) can lead to atri…

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A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis

Status: Recruiting

Brief Summary: A phase 1b/2 study of XTMAB-16 in patients with pulmonary sarcoidosis  

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Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis

Status: Recruiting

Brief Summary: This is a multicenter, randomized, double-blind, placebo-controlled, study comparing the efficacy and safety of intravenous (IV) efzofitimod 3 mg/kg and 5 mg/kg versus placebo after 48 weeks of treatment. This study will enroll adults with histologically confirmed pulmonary sarcoidosi…

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Risk Indicators of Sarcoidosis Evolution-Unified Protocol (RISE-UP)

Status: Recruiting

Brief Summary: The purpose of this study is to develop prediction models that can prognosticate patients with sarcoidosis using clinical data and blood markers that can be obtained during a clinic visit. Detailed Description: The purpose of this study is to develop prediction models that can prognos…

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Routine Cardiac Screening in Sarcoidosis Patients (PAPLAND)

Status: Recruiting

Brief Summary: This protocol is an unblended randomized screening trial will have consecutive patients with no suggestion of cardiac sarcoidosis according to usual screening enroll in an enhanced screening protocol. The routine clinical care is to gather patient’s history of symptoms and under go an…

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Use of CXCL9 as a Biomarker of Acthar Efficacy (Acthar)

Status: Recruiting

Brief Summary: The objective is this study is to test whether use of Acthar gel in the context of sarcoidosis will lead to improved symptoms and lung function and correlate with decreased levels of predictive blood biomarkers, like chemokine ligand 9 (CXCL9). Detailed Description: The investigators…

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Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis

Status: Recruiting

Brief Summary: The primary objective of this study was to determine the ability of cardiac magnetic resonance (CMR) to identify cardiac involvement in patients with sarcoidosis. Patients were to undergo CMR in addition to routine clinical evaluation. Detailed Description: In patients with sarcoidosi…

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Worldwide Sarcoidosis Research Study (WISE)

Status: Recruiting

Brief Summary: The aim of this study is to collect information about the clinical course and characteristics of sarcoidosis patients around the world through web-based surveys. Recruitment is directed at and driven by patients in the sarcoidosis community. This will allow the the investigators to st…

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Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis

Status: Recruiting

Brief Summary: Sarcoidosis is a multi-system granulomatous disorder that is triggered and influenced by gene-environment interactions. Although sarcoidosis predominantly affects the lungs in most cases, the clinical disease course is highly variable and any organ can be affected leading to end organ…

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Janus Kinase Inhibition in Sarcoidosis

Status: Recruiting

Brief Summary: The purpose of this study is to investigate the role of the oral JAK1 inhibitor, abrocitinib 200 mg once daily, for the treatment of patients with moderate to severe cutaneous sarcoidosis. Detailed Description: To determine if JAK1 specific inhibition is effective in treating sarcoido…

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Cardiac Sarcoidosis Randomized Trial

Status: Recruiting

Brief Summary: Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac sarcoidosis and not yet treated. The Investigators hypothesi…

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REgiStry Of the NAtural History of recurreNt periCarditis in pEdiatric and Adult Patients

Status: Recruiting

Brief Summary: The registry will focus on furthering the understanding of the natural history of recurrent pericarditis (RP), as well as document RP-related clinical, health-related quality of life (HRQoL), and economic burden and will assist the medical community to refine or develop data-driven re…

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Efficacy and Safety of RPH-104 Treatment in Patients With Recurrent Pericarditis

Status: Not yet recruiting

Brief Summary: The primary purpose of this study is the evaluation of the efficacy and safety of RPH-104 treatment in patients with recurrent pericarditis. Pharmacokinetic and pharmacodynamic parameters of RPH-104 multiple doses in this patient population will be assessed as well. Detailed Descripti…

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Impact of CardiolRxTM on Recurrent Pericarditis (MAvERIC-Pilot)

Status: Recruiting

Brief Summary: Patients with recurrent pericarditis who are refractory or intolerant to current therapeutic management options or who require long-term administration of corticosteroids to control their disease are particularly challenging to manage. The pathogenesis of pericarditis involves the act…

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Myocardial Injury and Dysfunction Associated with COVID-19 Vaccination

Status: Recruiting

Brief Summary: The overall goal of the study is to investigate the characteristics and potential mechanisms responsible for myocardial injury and dysfunction in patients after COVID-19 vaccination. Cardiac damage will be assessed with cardiac MRI and endomyocardial biopsy (EmBx) histopathology. Myoc…

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Mayo AVC Registry and Biobank

Status: Recruiting

Brief Summary: Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as…

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Abatacept in Immune Checkpoint Inhibitor Myocarditis

Status: Recruiting

Brief Summary: The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of…

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MYTHS – MYocarditis THerapy with Steroids

Status: Recruiting

Brief Summary: This is a phase III, multi-center international, single blind randomized controlled trial to test the efficacy of pulsed intravenous (IV) methylprednisolone versus standard therapy on top of maximal support in patients with Acute myocarditis (AM). Detailed Description: Acute myocardit…

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Impact of CardiolRx on Myocardial Recovery in Patients with Acute Myocarditis (ARCHER)

Status: Recruiting

Brief Summary: Multi-center, double-blind, placebo-controlled, parallel group design. Patients with myocarditis will be screened and, if eligible, randomized within 10 days of the diagnostic CMR to CardiolRx or placebo. The treatment period is 12 weeks; a last follow-up visit is scheduled one week a…

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Global Cardio Oncology Registry

Status: Recruiting

Brief Summary: G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increas…

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Cell Free DNA in Cardiac Sarcoidosis

Status: Recruiting

Brief Summary: Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing significant morbidity and mortality. Immunosuppressive ther…

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The ORCHESTRATE – Myocarditis Registry

Status: Not yet recruiting

Brief Summary: A retrospective, observational study consisting of patients who presents with typical/atypical chest pain and have an ensuing negative ischemic evaluation Detailed Description: Multicenter, retrospective, observational study consisting of patients who presents with typical/atypical ch…

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A Study to Learn About The COVID-19 (Study) Vaccine (Called COMIRNATY) in People That Are Less Than 21 Years Old.

Status: Recruiting

Brief Summary: The purpose of this clinical trial is to learn about the safety and effects of the study vaccine (called COMIRNATY) for the potential prevention of COVID-19. This study is seeking participants who: Are age <21 years. Have presentation to participating medical center with evaluation…

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Quantitative Cardiac Parametric Mapping

Status: Recruiting

The overall goal of this project is to evaluate the clinical potential of fast quantitative myocardial tissue characterization using recently emerged Cardiac Magnetic Resonance Imaging (CMR) techniques to aid the diagnosis, treatment, and follow up of patients with myocardial diseases, such as ische…

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Myocarditis Causing Premature Ventricular Contractions: Insights From the MAVERIC Registry

Status: Not yet recruiting

Brief Summary: To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up. Detailed Description: Hypothesized…

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