Are you or a loved one living with the challenges of myocarditis, pericarditis, or sarcoidosis? The Myocarditis Foundation is dedicated to improving the lives of those affected by these heart conditions, and you can play a vital role in advancing the cure. Participating in a clinical trial is not only an opportunity to receive cutting-edge medical care but also a chance to contribute to groundbreaking research that can transform the future of cardiac health. By joining a clinical trial, you become a beacon of hope for countless individuals around the world who yearn for better treatments and ultimately, a cure. Your participation can be the difference-maker in our journey towards a world without the burden of myocarditis, pericarditis, and sarcoidosis.
Clinical trials offer numerous benefits to participants beyond the potential for life-changing breakthroughs. When you participate, you receive close monitoring from leading healthcare experts who specialize in myocarditis, pericarditis, and sarcoidosis. You gain access to cutting-edge therapies, often before they become widely available, which can significantly improve your quality of life. Additionally, your involvement helps researchers gather critical data, paving the way for more targeted and effective treatments. Every trial participant is a hero in our quest to conquer these conditions, and your contribution is invaluable.
At the Myocarditis Foundation, we firmly believe that together, we can make a difference. We urge you to consider participating in a clinical trial as a powerful way to advocate for yourself and others affected by myocarditis, pericarditis, and sarcoidosis. However, it’s important to note that the Myocarditis Foundation is not affiliated with these research studies, and we are not accountable for the results or outcomes of specific clinical trials.
Join us in the fight against these heart conditions, and together, we can build a healthier and happier future for all.
Clinical Trials, What They Are and Why They Are So Important
Cardiovascular Multimodality Imaging Study
Status: Recruiting
Brief Summary Determining the etiology of cardiomyopathy is of high clinical importance for optimal treatment strategy and prediction of prognosis. There is increased risk for cardiovascular disease and higher propensity for cardiovascular related mortality among Black and non-Hispanic White patient…
Read moreCZI Rare As One: Co-designing an App and Wearable Based Compass for Rare Diseases
Status: Active, Recruiting
Brief Summary The CZI Rare As One study is a Chan Zuckerberg Initiative funded study that aims to co-design and pilot test unique symptom tracking and transmitting apps across 5 different sub-arms that includes individuals with Long COVID, Pancreatitis, Sarcoidosis, Vasolin-Containing Protein (VCP)…
Read moreClinical Trial to Assess the Safety of a Novel Scaffold Biomaterial
Status: Active not recruiting
Brief Summary This is safety study. Subjects will be undergoing the surgical procedure of nerve biopsy. After routine surgery without grafting, patients develop swelling, redness, tenderness and dysesthesia at the biopsy site. In order to determine whether grafting is safe compared to not repairing…
Read moreCOR-INSIGHT: Optimizing Cardiovascular and Cardiopulmonary Outcomes with AI-Driven Multiplexed Indications Using COR ECG Wearable (COR-INSIGHT)
Status: Enrolling by invitation
Brief Summary The COR-INSIGHT trial aims to evaluate the effectiveness of Peerbridge COR advanced ambulatory ECG wearables (COR 1.0 and COR 2.0) in accurately and non-invasively detecting cardiovascular and cardiopulmonary conditions using AI-based software (CardioMIND and CardioQSync). The study de…
Read moreAn Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis
Status: Recruiting
Brief Summary This is a study to understand if taking VTX2735 is safe and effective in participants diagnosed with Recurrent Pericarditis (RP). Approximately 30 patients will take VTX2735. The study consists of a 30-day Screening Period (to see if a participant qualifies for the study), a 6-week Ope…
Read moreGlobal Cardio Oncology Registry (G-COR)
Status: Recruiting
Brief Summary G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increase…
Read moreMyocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry (MAVERIC)
Status: Not yet recruiting
Brief Summary To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up. Detailed Description Hypothesized th…
Read moreMyocardial Inflammation in Systemic Lupus Erythematosus
Status: Not yet recruiting
Brief Summary The goal is to assess for myocardial edema on cardiac MRI during SLE flare to assess for myocardial inflammation. Detailed Description The over-arching goal of this work is to further the understanding of myocardial damage in systemic lupus erythematosus (SLE) using state of the art CV…
Read moreThe ORCHESTRATE-Myocarditis Registry
Status: Not yet recruiting
Brief Summary A retrospective, observational study consisting of patients who presents with typical/atypical chest pain and have an ensuing negative ischemic evaluation Detailed Description Multicenter, retrospective, observational study consisting of patients who presents with typical/atypical ches…
Read moreA Study to Assess Long-term Outcomes of Myocarditis Following Administration of COVID-19 mRNA Vaccine (SPIKEVAX)
Status: Not yet recruiting
Brief Summary The main goal of this study is to characterize presentation, clinical course, and long-term outcomes of myocarditis temporally associated with administration of mRNA-1273 (SPIKEVAX) COVID-19 vaccine Detailed Description This is an observational cohort study that combines data collected…
Read moreVitamin D Homeostasis in Sarcoidosis
Status: Recruiting
Brief Summary This study evaluates the relationship between vitamin-D status and severity of sarcoidosis, and the effects of vitamin-D repletion in vitamin-D insufficient patients with sarcoidosis. Half the patients with sarcoidosis who are vitamin-D insufficient will receive standard vitamin-D supp…
Read moreDiagnostic Utility of SGLT1/
Status: Recruiting
Brief Summary: This is a pilot mechanistic study of the diagnostic utility of sodium-glucose cotransporter-1/2 inhibition (SGLT1/2) on myocardial glucose suppression on FDG PET/CT. The investigators will test whether the addition of a SGLT1/2 inhibitor (SGLT1/2i) plus the standard dietary modificati…
Read moreCardiolRx in Recurrent Pericarditis Following IL-1 Blocker Cessation (MAVERIC)
Status: Recruiting
Brief Summary: Multi-center, randomized, double-blind, placebo-controlled, phase-3 Trial. Patients with a history of recurrent pericarditis who are being treated with an IL-1 blocker for at least 12 months, scheduled to be discontinued, will be approached for potential trial participation. Double-bl…
Read moreRilonacept in Subjects with Cardiac Sarcoidosis
Status: Recruiting
Brief Summary: The primary objective of this study is to evaluate the effect of rilonacept, added to standard therapy and compared with standard therapy alone, on improvement in myocardial inflammation in subjects with cardiac sarcoidosis after 24 weeks of therapy.
Read moreFDG-PET As an Imaging Modality to Diagnose and Risk Stratify Subclinical, Imaging Negative Ici-Myocarditis
Status: Recruiting
Brief Summary: The purpose of this pilot study is to evaluate Fluorodeoxyglucose – Positron Emission Tomography (FDG-PET) as an imaging modality to diagnose and risk stratify subclinical, imaging negative ICI-myocarditis, and to determine whether subclinical ICI-induced myocarditis is a distinct and…
Read moreA Study to Learn About The COVID-19 (Study) Vaccine (Called COMIRNATY) in People That Are Less Than 21 Years Old.
Status: Recruiting
Brief Summary The purpose of this clinical trial is to learn about the safety and effects of the study vaccine (called COMIRNATY) for the potential prevention of COVID-19. This study is seeking participants who: Are age <21 years. Have presentation to participating medical center with evaluation…
Read moreEfficacy and Safety Study of OATD-01 in Patients With Active Pulmonary Sarcoidosis
Status: Recruiting
Brief Summary: This is a Phase 2, randomized, double-blind, placebo-controlled, adaptive, multicenter study to evaluate the efficacy, safety, tolerability, Pharmacodynamics (PD), and Pharmacokinetics (PK) of OATD-01 in the treatment of subjects with active pulmonary sarcoidosis. Detailed Description…
Read moreMayo AVC Registry and Biobank
Status: Recruiting
Brief Summary: Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous. Diagnosis and screening of blood-relatives is very difficult as…
Read moreCell Free DNA in Cardiac Sarcoidosis (cfDNA in CS)
Status: Recruiting
Brief Summary:Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing significant morbidity and mortality. Immunosuppressive thera…
Read moreUTSW HP [13-C] Pyruvate Injection in HCM (HPHCM)
Status: Recruiting
Brief Summary: The study objective is to identify the earliest changes in energy substrate metabolism in patients with cardiomyopathies (CMP). To achieve this objective, we plan first to test the hypothesis that patients with CMP present focal alterations in myocardial hyperpolarized [1-13C]pyruvate…
Read moreFoundation for Sarcoidosis Research Advanced Cures Registry (FSR-SARC Registry)
Status: Recruiting
Brief Summary: The goal of the study is to create a longitudinal study of patient reported outcomes for people living with sarcoidosis that maintains privacy. Patients report on the following: demographics, disease symptoms, diagnostic journey, provider experience, disease treatment, and burden of d…
Read moreRole of Endomyocardial Biopsy and Etiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management
Status: Recruiting
Brief Summary: this multicenter registry, both retrospective and prospective, aims at answering multiple questions about myocarditis, with special attention to arrhythmic manifestations. Patients with myocarditis proven at least by endomyocardial biopsy and/or cardiac magnetic resonance will be enro…
Read moreRole of Novel ILR in the Management of PVCs
Status: Recruiting
Brief Summary: This prospective, observational study is a single center clinical registry of patients referred for management of symptomatic or asymptomatic Premature Ventricular Contractions (PVCs). Subjects will be followed through 12 months. The study will enroll approximately 50 patients. Detail…
Read moreRheumatology Patient Registry and Biorepository
Status: Recruiting
Brief Summary: To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases. Detailed Description: A rheumatology biorepository will be created to permit comparative analyses between the rheumatic diseases in order to increase the understanding…
Read moreA Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants With Progressive Pulmonary Fibrosis
Status: Recruiting
Brief Summary: The purpose of this study is to evaluate the efficacy, safety, and tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis.
Read moreInterstitial Lung Disease Research Unit Biobank
Status: Recruiting
Brief Summary: Establish a interstitial lung disease (ILD) registry and biorepository to lead towards a further understanding of the disease. Detailed Description: The University of Kansas ILD and Rare Lung Disease clinic sees hundreds of new patients per year. The investigators would like to levera…
Read moreA Study of the Natural Progression of Interstitial Lung Disease
Status: Recruiting
Brief Summary: We propose to acquire data and blood samples on all patients being cared for by the Interstitial Lung Disease (ILD) program. Additionally, we will collect data and blood samples from a control group for comparator purposes. In doing so, we will be able to describe the “phenotypic” exp…
Read moreInhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension
Status: Recruiting
Brief Summary: This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension. Detailed Description: Pulmonary sarcoidosis-associated pulmonary hypertension is classified as WHO Group 5 pulmonar…
Read moreDiagnostic Yield of Intranodal Forceps Biopsies in Mediastinal Adenopathy
Status: Recruiting
Brief Summary: The investigators will compare endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) with intranodal forceps biopsy (EBUS-IFB) as it relates to the rate of diagnosis of suspected sarcoidosis. Detailed Description: This is prospective, single center randomized comparati…
Read moreFull-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens
Status: Recruiting
Brief Summary: This study sets out to register imaging of small biopsy specimens obtained during bronchoscopy using full-field optical coherence tomography against standard histologic evaluation. Detailed Description: Small biopsy specimens obtained through bronchoscopy are commonly employed for the…
Read moreMedication Adherence in Patients With Sarcoidosis
Status: Recruiting
Brief Summary: The goal of the study is to look at the relationship between how individuals with Sarcoidosis take the sarcoidosis medicines and how it affects the disease, to evaluate any factors that may make individuals not want to take the medicines, and to develop and refine ways to help support…
Read moreA Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
Status: Recruiting
Brief Summary: A phase 1b/2 study of XTMAB-16 in patients with pulmonary sarcoidosis
Read moreRisk Indicators of Sarcoidosis Evolution-Unified Protocol (RISE-UP)
Status: Recruiting
Brief Summary: The purpose of this study is to develop prediction models that can prognosticate patients with sarcoidosis using clinical data and blood markers that can be obtained during a clinic visit. Detailed Description: The purpose of this study is to develop prediction models that can prognos…
Read moreUse of CXCL9 as a Biomarker of Acthar Efficacy (Acthar)
Status: Recruiting
Brief Summary: The objective is this study is to test whether use of Acthar gel in the context of sarcoidosis will lead to improved symptoms and lung function and correlate with decreased levels of predictive blood biomarkers, like chemokine ligand 9 (CXCL9). Detailed Description: The investigators…
Read moreDelayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis
Status: Recruiting
Brief Summary: The primary objective of this study was to determine the ability of cardiac magnetic resonance (CMR) to identify cardiac involvement in patients with sarcoidosis. Patients were to undergo CMR in addition to routine clinical evaluation. Detailed Description: In patients with sarcoidosi…
Read moreEpigenetic Regulation of Altered T-cell Immunity in Sarcoidosis
Status: Recruiting
Brief Summary: Sarcoidosis is a multi-system granulomatous disorder that is triggered and influenced by gene-environment interactions. Although sarcoidosis predominantly affects the lungs in most cases, the clinical disease course is highly variable and any organ can be affected leading to end organ…
Read moreCardiac Sarcoidosis Randomized Trial
Status: Recruiting
Brief Summary: Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac sarcoidosis and not yet treated. The Investigators hypothesi…
Read moreREgiStry Of the NAtural History of recurreNt periCarditis in pEdiatric and Adult Patients (Resonance)
Status: Active not recruiting
Brief Summary: The registry will focus on furthering the understanding of the natural history of recurrent pericarditis (RP), as well as document RP-related clinical, health-related quality of life (HRQoL), and economic burden and will assist the medical community to refine or develop data-driven re…
Read moreEfficacy and Safety of RPH-104 Treatment in Patients With Recurrent Pericarditis
Status:
Brief Summary: The primary purpose of this study is the evaluation of the efficacy and safety of RPH-104 treatment in patients with recurrent pericarditis. Pharmacokinetic and pharmacodynamic parameters of RPH-104 multiple doses in this patient population will be assessed as well. Detailed Descripti…
Read moreAbatacept in Immune Checkpoint Inhibitor Myocarditis
Status: Recruiting
Brief Summary: The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of…
Read moreMYTHS – MYocarditis THerapy with Steroids
Status: Recruiting
Brief Summary: This is a phase III, multi-center international, single blind randomized controlled trial to test the efficacy of pulsed intravenous (IV) methylprednisolone versus standard therapy on top of maximal support in patients with Acute myocarditis (AM). Detailed Description: Acute myocardit…
Read moreGlobal Cardio Oncology Registry (G-COR)
Status: Recruiting
Brief Summary: G-COR is the first Global Prospective Cardio-Oncology Registry. It is a multinational, multicenter prospective observational cohort registry, with the goal of collecting clinical, laboratory, imaging, demographic, and socioeconomic data to identify risk factors associated with increas…
Read moreA Study to Learn About The COVID-19 (Study) Vaccine (Called COMIRNATY) in People That Are Less Than 21 Years Old.
Status: Recruiting
Brief Summary: The purpose of this clinical trial is to learn about the safety and effects of the study vaccine (called COMIRNATY) for the potential prevention of COVID-19. This study is seeking participants who: Are age <21 years. Have presentation to participating medical center with evaluation…
Read moreQuantitative Cardiac Parametric Mapping
Status: Recruiting
Brief Summary: The overall goal of this project is to evaluate the clinical potential of fast quantitative myocardial tissue characterization using recently emerged Cardiac Magnetic Resonance Imaging (CMR) techniques to aid the diagnosis, treatment, and follow up of patients with myocardial diseases…
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