Abatacept in Immune Checkpoint Inhibitor Myocarditis

Abatacept in Immune Checkpoint Inhibitor Myocarditis

Status: Recruiting

Conditions: Myocarditis


"Beth Israel Deaconess Medical Center "
Allegheny-Singer Research Institution
Boston Medical Center
Brigham and Women's Hospital
Cedars-Sinai Medical Center
Lehigh Valley Health Network
Memorial Sloan Kettering Cancer Center
University of California Los Angeles
University of Kansas Medical Center
University of Kentucky
University of Michigan
University of North Carolina Chapel Hill
University of Texas Southwestern
University of Utah


Los Angeles, California

Los Angeles, California

Kansas City, Kansas

Lexington, Kentucky

Boston, Massachusetts

Ann Arbor, Michigan

New York, New York

Chapel Hill, North Carolina

Bethlehem, Pennsylvania

Pittsburgh, Pennsylvania

Dallas, Texas

Houston, Texas

Salt Lake City, Utah

Contact Information:

Kiranbir Josan, MD

Eric Yang, MD

Charles Porter, MD

Amit Arbune, MD

Daniel Zlotoff, MD, PhD 617-726-2000 [email protected]

Aarti Asnani or Abul Aritizia, MD

Omar Siddiqi

Anju Nohria, MD [email protected]

Salim Hayek, MD [email protected]

Dipti Gupta, MD

Brian Jensen, MD

Nicholas Trask

Valentyna Ivanova

Saketh Nadimpalli [email protected]

Nicolas Palaskas [email protected]

Anees Daud, MD

The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.

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