Role of Endomyocardial Biopsy and Etiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management
Status: Recruiting
Conditions: Myocarditis
Location:
IRCCS San Raffaele Scientific InstituteCity/State:
Milan, Italy
Contact Information:
Giovanni Peretto, MD
+39 (022) 643-7482
[email protected]
Brief Summary:
this multicenter registry, both retrospective and prospective, aims at answering multiple questions about myocarditis, with special attention to arrhythmic manifestations. Patients with myocarditis proven at least by endomyocardial biopsy and/or cardiac magnetic resonance will be enrolled, and characterized by means of multimodality diagnostic workup, both at baseline and during follow-up. The following unsolved questions will be addressed:
-to report the prevalence of arrhythmias in myocarditis
-to describe the relationships between arrhythmia features and myocardial inflammatory status
-to identify predictors of sudden cardiac death in acute myocarditis and chronic inflammatory cardiomyopathy with arrhythmic vs. non-arrhythmic clinical onset
-to investigate safety and effectiveness of immunomodulatory treatment strategies in arrhythmic and non-arrhythmic myocarditis
-to investigate safety and effectiveness of catheter ablation ablation to target myocarditis-associated arrhythmias
-to describe clinical presentation and arrhythmic outcomes of genetic forms of myocarditis
-to describe clinical presentation and arrhythmic outcomes of myocarditis associated with systemic rheumatologic diseases
