Use of CXCL9 as a Biomarker of Acthar Efficacy (Acthar)

Use of CXCL9 as a Biomarker of Acthar Efficacy (Acthar)

Status: Recruiting

Conditions: Sarcoidosis


University of California- San Francisco


San Fransisco, California

Contact Information:

Laura Koth, MD
(415) 514-4369
[email protected]

Brief Summary:
The objective is this study is to test whether use of Acthar gel in the context of sarcoidosis will lead to improved symptoms and lung function and correlate with decreased levels of predictive blood biomarkers, like chemokine ligand 9 (CXCL9).
Detailed Description:
The investigators will test whether Acthar gel’s anti-inflammatory properties will modulate immune cells and lead to decreases in blood biomarkers and improvements in clinical parameters. Specific Aim 1 will examine the levels of the predictive biomarker, chemokine ligand 9 (CXCL9), and related transcripts, and determine whether they decrease in participants over time while taking Acthar. Specific Aim 2 will test whether the biologic changes measured in blood correlate to clinical markers, including lung function and symptom scores. Since the investigators have found that CXCL9 predicts clinical course, they hypothesize that CXCL9 transcript levels in the blood will decrease over time in pulmonary sarcoidosis participants whose clinical outcome measures improve with Acthar.
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