Vitamin D Homeostasis in Sarcoidosis
Status: Recruiting
Conditions: Sarcoidosis
Location:
University of Texas SouthwesternCity/State:
Dallas, Texas
Contact Information:
Name: Connie Hsia, MD
Phone Number: 2146483426
Email: [email protected]
Name: Khashayar Sakhaee, MD
Phone Number: 2146480324
Email: [email protected]
Sarcoidosis is a multi-system inflammatory disease characterized by T-helper lymphocyte hyperactivity leading to granulomatous inflammation. The granuloma cells autonomously convert 25-hydroxy-vitamin-D (25OHD) to the active metabolite 1,25-dihydroxy-vitamin-D (1,25OH2D) independent of normal feedback control but dependent on substrate (25OHD) concentration.
Circulating 1,25OH2D exerts both anti-inflammatory and mineral metabolic actions. Deficiency of 25OHD limits substrate-dependent 1,25OH2D synthesis, diminishes anti-antigenic innate immunity and augments pro-inflammatory adaptive immunity. Thus, low vitamin-D stores could aggravate sarcoid inflammation while repletion of vitamin-D stores could mitigate inflammation in sarcoidosis.