The Myocarditis Foundation is proud to announce that we have awarded a Post-Doctoral Research Grant, co-funded with the American Heart Association, for the Academic years of 2018-2020 to Dr. Lindsey Bazzone, MD, PhD., of the University of Massachusetts Medical School.
Dr. Bazzone’s research entitled: “The Role of ADAMS in the Immunopathogenesis of Viral Myocarditis” was reviewed by members of our Medical Advisory Board and decided on by our Board of Directors. This research is the most integrative with a human protein target in both in-vitro and mouse experiments.
Viral myocarditis is an inflammatory disease of the heart that results in significant morbidity and mortality and may account for up to 42% of unexplained deaths in patients 35 years old or younger. Picornavirus infections are thought to be a major cause of myocarditis in humans and animals; however, the underlying pathogenesis of viral myocarditis remains largely unclear. Virus-host cell receptor interactions are implicated as important mediators of pathogenesis. This proposal will examine the role of the human protein, ADAM9, in viral myocarditis. Using functional and mechanistic studies in knockout cell lines and mouse models, we will determine the function of ADAM9 in the activation of innate antiviral immunity and disease progression to myocarditis during picornavirus infection.
Our congratulations to Dr. Lindsey Bazzone and many thanks for your work in myocarditis research!