Dr. David Marchant of the University of British Columbia in Vancouver, Canada

Awarded grant in 2009

Discovering and Understanding Virus-Host Factor Interactions for Treatment of Viral Myocarditis

Dr. David Marchant of the University of British Columbia in Vancouver, Canada

“We showed that virus signaling during infection originated from, and converge upon, dominant signaling ‘nodes.’  This work, which employed several signaling inhibitors to investigate signaling ‘networks,’ identified those target whose inhibition most effectively inhibited viral replication; the ‘nodes.’

We concluded that by targeting the dominant signaling nodes that are required for viral replication we could, hypothetically, discover the most effective target for treatment of CVB3 infection.  This is the first work of its kind and should provide new avenues for investigation of the most effective antivirals for treatment of virally induced myocarditis.”