Dr. Silvio Antoniak of the University of North Carolina in Chapel Hill

Awarded grant in 2009

Thrombin-PAR-1 Signaling in Viral Myocarditis

Dr. Silvio Antoniak of the University of North Carolina in Chapel Hill

“I conclude that PAR-1 activation is essential in the early phase of virus infection to manage an effective immune response against CVB3. This response is maintained by a successful recognition of virus’ antigens by the TLR-3 pathway and a PAR-1 dependent NK cell activation. The altered immune reaction in PAR-1-/- mice leads to uncontrolled virus replication and later to an over-bursting immune response, aberrant cardiac remodeling leading to cardiac dysfunction after CVB3 infection.”