IRCCS San Raffaele Scientific Institute

Brief Summary:

• nonischemic cardiomyopathies (NICM) constitute a heterogeneous group of diseases characterized by distinct structural and functional myocardial abnormalities in the absence of obstructive epicardial coronary artery disease. To date, there is a huge lack of knowledge related to two main aspects of NICM, namely the “arrhythmogenic” and the “inflammatory” phenotypes, hereby named as AINICM. This study is multicenter, observational and both retrospective and prospective and aims to answer multiple unsolved questions in the field of AINICM:
• Improving the diagnostic workup
• Identifying disease-specific signatures
• Working our models for risk prediction
• Tailoring treatment strategies
• Allowing direct comparison among specific NICM subgroups, i.e. dilated, hypertrophic, nondilated, arrhythmogenic, restrictive, and other rare cardiomyopathies.

Brief Summary:

this multicenter registry, both retrospective and prospective, aims at answering multiple questions about myocarditis, with special attention to arrhythmic manifestations. Patients with myocarditis proven at least by endomyocardial biopsy and/or cardiac magnetic resonance will be enrolled, and characterized by means of multimodality diagnostic workup, both at baseline and during follow-up. The following unsolved questions will be addressed: