IRCCS San Raffaele Scientific Institute

Multimodal and Multidisciplinary Approach to optimize Diagnostic, Prognostic, and Therapeutic management of Patients with Nonischemic Cardiomyopathies and Arrhyhmogenic-Inflammatory phenotypes

Status: Recruiting

Location: IRCCS San Raffaele Scientific Institute

Conditions: IRCCS San Raffaele Scientific Institute

City/State:

Milan, Italy

Contact Information:

Giovanni Peretto, MD
+39 (022) 643-7482
[email protected]

Brief Summary:

  • nonischemic cardiomyopathies (NICM) constitute a heterogeneous group of diseases characterized by distinct structural and functional myocardial abnormalities in the absence of obstructive epicardial coronary artery disease. To date, there is a huge lack of knowledge related to two main aspects of NICM, namely the “arrhythmogenic” and the “inflammatory” phenotypes, hereby named as AINICM. This study is multicenter, observational and both retrospective and prospective and aims to answer multiple unsolved questions in the field of AINICM:
  • Improving the diagnostic workup
  • Identifying disease-specific signatures
  • Working our models for risk prediction
  • Tailoring treatment strategies
  • Allowing direct comparison among specific NICM subgroups, i.e. dilated, hypertrophic, nondilated, arrhythmogenic, restrictive, and other rare cardiomyopathies.
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Role of Endomyocardial Biopsy and Etiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management

Status: Recruiting

Location: IRCCS San Raffaele Scientific Institute

Conditions: IRCCS San Raffaele Scientific Institute

City/State:

Milan, Italy

Contact Information:

Giovanni Peretto, MD
+39 (022) 643-7482
[email protected]

Brief Summary:

this multicenter registry, both retrospective and prospective, aims at answering multiple questions about myocarditis, with special attention to arrhythmic manifestations. Patients with myocarditis proven at least by endomyocardial biopsy and/or cardiac magnetic resonance will be enrolled, and characterized by means of multimodality diagnostic workup, both at baseline and during follow-up. The following unsolved questions will be addressed:

-to report the prevalence of arrhythmias in myocarditis

-to describe the relationships between arrhythmia features and myocardial inflammatory status

-to identify predictors of sudden cardiac death in acute myocarditis and chronic inflammatory cardiomyopathy with arrhythmic vs. non-arrhythmic clinical onset

-to investigate safety and effectiveness of immunomodulatory treatment strategies in arrhythmic and non-arrhythmic myocarditis

-to investigate safety and effectiveness of catheter ablation ablation to target myocarditis-associated arrhythmias

-to describe clinical presentation and arrhythmic outcomes of genetic forms of myocarditis

-to describe clinical presentation and arrhythmic outcomes of myocarditis associated with systemic rheumatologic diseases

 

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